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Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis

14 Jun 2022

Abstract excerpt

The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice, deletion of the Fanconi anemia (FA) genes Fanca and Fancc dampened HSC regeneration through direct effects on HSCs and indirect effects on BM niche cells. FA HSCs showed persistent upregulation of the Wnt target Prox1 in response to total body irradiation (TBI)....

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PMID: 35703178
DOI: 10.1172/jci155914

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