Article
Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition.
BMC cancer - 17 May 2016
Davis McKale R, Daggett Juliane J, Pascual Agnes S, Lam Jessica M, Leyva Kathryn J, Cooper Kimbal E, Hull Elizabeth E
Abstract excerpt
BACKGROUND: The BRM and BRG1 tumor suppressor genes are mutually exclusive ATPase subunits of the SWI/SNF chromatin remodeling complex. The human adrenal carcinoma SW13 cell line can switch between a subtype which expresses these subunits, SW13+, and one that expresses neither subunit, SW13-. Loss of BRM expression occurs post-transcriptionally and can be restored via histone deacetylase (HDAC) inhibition....
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