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Article

Novel MicroRNA Regulators of Atrial Natriuretic Peptide Production.

Molecular and cellular biology - 15 Jul 2016

Wu Connie, Arora Pankaj, Agha Obiajulu, Hurst Liam A, Allen Kaitlin, Nathan Daniel I, Hu Dongjian, Jiramongkolchai Pawina, Smith J Gustav, Melander Olle, Trenson Sander, Janssens Stefan P, Domian Ibrahim, Wang Thomas J, Bloch Kenneth D, Buys Emmanuel S, Bloch Donald B, Newton-Cheh Christopher

Abstract excerpt

Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs typically contain multiple predicted microRNA (miRNA)-binding sites, and binding of different miRNAs may independently or coordinately regulate the expression of any given mRNA. We used a...

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Identifiers

PMID: 27185878
DOI: 10.1128/MCB.01114-15
PMCID: PMC4936060

Genes

NPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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