Article
SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction.
American journal of hypertension - 1 Sept 2011
Nossent A Yaël, Hansen Jakob L, Doggen Carine, Quax Paul H A, Sheikh Søren P, Rosendaal Frits R
Abstract excerpt
BACKGROUND: We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction. METHODS: Using online databases dbSNP and TargetScan, we identified 10 SNPs in potential miR binding sites in eight RAAS-related genes, common in Caucasians. We genotyped a large...
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