Natural antisense transcript of natriuretic peptide precursor A (NPPA): structural organization and modulation of NPPA expression

Abstract excerpt

BACKGROUND: Mammalian transcriptome contains a large proportion of diverse and structurally complex noncoding RNAs. One class of such RNAs, natural antisense transcripts (NATs), are derived from the opposite strand of many protein-coding genes. Although the exact structure and functional relevance of most of the NATs is unknown, their emerging role as gene expression regulators raises the hypothesis that NATs...

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