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Article

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility.

Antimicrobial agents and chemotherapy - 1 Oct 2005

Yen Hui-Ling, Herlocher Louise M, Hoffmann Erich, Matrosovich Mikhail N, Monto Arnold S, Webster Robert G, Govorkova Elena A

Abstract excerpt

Mutations of the conserved residues of influenza virus neuraminidase (NA) that are associated with NA inhibitor (NAI) resistance decrease the sialidase activity and/or stability of the NA, thus compromising viral fitness. In fact, clinically derived NAI-resistant variants with different NA mutations have shown different transmissibilities in ferrets (M. L. Herlocher, R. Truscon, S. Elias, H. Yen, N. A. Roberts,...

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Identifiers

PMID: 16189083
DOI: 10.1128/AAC.49.10.4075-4084.2005
PMCID: PMC1251536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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