Article
IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology.
Mucosal immunology - 1 Mar 2015
Chen Lili, He Zhengxiang, Slinger Erik, Bongers Gerold, Lapenda Taciana L S, Pacer Michelle E, Jiao Jingjing, Beltrao Monique F, Soto Alan J, Harpaz Noam, Gordon Ronald E, Ochando Jordi C, Oukka Mohamed, Iuga Alina Cornelia, Chensue Stephen W, Blander Julie Magarian, Furtado Glaucia C, Lira Sergio A
Abstract excerpt
Interleukin-23 (IL-23) responsive group 3 innate lymphoid cells (ILC3s) have been implicated in immune homeostasis and pathogenesis in the adult, but little is known about their roles in the newborn. Here we show that IL-23 promotes conversion of embryonic intestinal Lin(-)IL-23R(+)Thy1(+) cells into IL-22-producing Thy1(+)Sca-1(hi) ILC3s in vitro. Gut-specific expression of IL-23 also activated and expanded...
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