Article
Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution.
Atherosclerosis - 1 Jul 2016
Patel Aniruddh P, Peloso Gina M, Pirruccello James P, Johansen Christopher T, Dubé Joseph B, Larach Daniel B, Ban Matthew R, Dallinge-Thie Geesje M, Gupta Namrata, Boehnke Michael, Abecasis Gonçalo R, Kastelein John J P, Hovingh G Kees, Hegele Robert A, Rader Daniel J, Kathiresan Sekar
Abstract excerpt
OBJECTIVE: Genome-wide association studies (GWAS) for plasma lipid levels have mapped numerous genomic loci, with each region often containing many protein-coding genes. Targeted re-sequencing of exons is a strategy to pinpoint causal variants and genes. METHODS: We performed solution-based hybrid selection of 9008 exons at 939 genes within 95 GWAS loci for plasma lipid levels and sequenced using next-generation...
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