Article
Genetic Variants in Severe Hypertriglyceridemia Among Taiwanese Participants - Insights From Genome-Wide Association and Whole-Exome Sequencing Analyses.
Circulation journal : official journal of the Japanese Circulation Society - 25 Feb 2025
Fan Hsien-Yu, Tsai Ming-Chieh, Lai Chih-Jun, Yeh Chiu-Li, Hsu Hsin-Yin, Lai Po-Jui, Hsu Hsiu-Ching, Su Ta-Chen, Lin Hung-Ju, Lin Yen-Feng, Lu Tzu-Pin, Chien Kuo-Liong
Abstract excerpt
BACKGROUND: There are limited data on the use of whole-exome sequencing (WES) to diagnose severe hypertriglyceridemia. Our aim was to identify candidate genes linked to triglyceride levels via a genome-wide association study (GWAS) and to recruit participants with severe hypertriglyceridemia for WES to assess allelic variants in the candidate genes. METHODS AND RESULTS: A GWAS was conducted involving 120,140...
Topics
Join the communities discussing this publication.