Article
mRNA expression levels and genetic status of genes involved in the EGFR and NF-κB pathways in metastatic non-small-cell lung cancer patients.
Journal of translational medicine - 27 Sept 2011
Santarpia Mariacarmela, Magri Ignacio, Sanchez-Ronco Maria, Costa Carlota, Molina-Vila Miguel Angel, Gimenez-Capitan Ana, Bertran-Alamillo Jordi, Mayo Clara, Benlloch Susana, Viteri Santiago, Gasco Amaya, Mederos Nuria, Carcereny Enric, Taron Miquel, Rosell Rafael
Abstract excerpt
BACKGROUND: Metastatic non-small-cell lung cancer (NSCLC) has a dismal prognosis. EGFR is overexpressed or mutated in a large proportion of cases. Downstream components of the EGFR pathway and crosstalk with the NF-κB pathway have not been examined at the clinical level. We explored the prognostic significance of the mRNA expression of nine genes in the EGFR and NF-κB pathways and of BRCA1 and RAP80 in patients...
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