Article
The place of targeted therapies in the management of non-small cell bronchial carcinoma. Molecular markers as predictors of tumor response and survival in lung cancer.
Revue des maladies respiratoires - 1 Nov 2006
Rosell R, Moran T, Fernanda Salazar M, Mendez P, De Aguirre I, Ramirez J-L, Isla D, Cobo M, Camps C, Lopez-Vivanco G, Alberola V, Taron M
Abstract excerpt
This review highlights the numerous molecular biology findings in the field of lung cancer with potential therapeutic impact in both the near and distant future. Abundant pre-clinical and clinical data indicate that BRCA1 mRNA expression is a differential modulator of chemotherapy sensitivity. Low levels predict cisplatin sensitivity and antimicrotubule drug resistance, and the opposite occurs with high levels....
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