Article
Microsatellite genotyping and genome-wide single nucleotide polymorphism-based indices of Plasmodium falciparum diversity within clinical infections.
Malaria journal - 12 May 2016
Murray Lee, Mobegi Victor A, Duffy Craig W, Assefa Samuel A, Kwiatkowski Dominic P, Laman Eugene, Loua Kovana M, Conway David J
Abstract excerpt
BACKGROUND: In regions where malaria is endemic, individuals are often infected with multiple distinct parasite genotypes, a situation that may impact on evolution of parasite virulence and drug resistance. Most approaches to studying genotypic diversity have involved analysis of a modest number of polymorphic loci, although whole genome sequencing enables a broader characterisation of samples. METHODS: PCR-based...
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