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Article

Characterization of within-host Plasmodium falciparum diversity using next-generation sequence data.

PloS one - 1 Jan 2012

Auburn Sarah, Campino Susana, Miotto Olivo, Djimde Abdoulaye A, Zongo Issaka, Manske Magnus, Maslen Gareth, Mangano Valentina, Alcock Daniel, MacInnis Bronwyn, Rockett Kirk A, Clark Taane G, Doumbo Ogobara K, Ouédraogo Jean Bosco, Kwiatkowski Dominic P

Abstract excerpt

Our understanding of the composition of multi-clonal malarial infections and the epidemiological factors which shape their diversity remain poorly understood. Traditionally within-host diversity has been defined in terms of the multiplicity of infection (MOI) derived by PCR-based genotyping. Massively parallel, single molecule sequencing technologies now enable individual read counts to be derived on genome-wide...

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PMID: 22393456
DOI: 10.1371/journal.pone.0032891
PMCID: PMC3290604

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