Article
Adaptive differentiation of Plasmodium falciparum populations inferred from single-nucleotide polymorphisms (SNPs) conferring drug resistance and from neutral SNPs.
The Journal of infectious diseases - 1 Oct 2010
Maïga-Ascofaré Oumou, Le Bras Jacques, Mazmouz Rabia, Renard Emmanuelle, Falcão Sarah, Broussier Emeline, Bustos Dorina, Randrianarivelojosia Milijaona, Omar Sabah A, Aubouy Agnès, Lepère Jean-François, Jean-François Vély, Djimdé Abdoulaye A, Clain Jérôme
Abstract excerpt
BACKGROUND: Theoretical and experimental data support the geographic differentiation strategy as a valuable tool for detecting loci under selection. In the context of Plasmodium falciparum malaria, few populations have been studied, with limited genomic coverage. METHODS: We examined geographic d...
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