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Article

CD44 variant-dependent redox status regulation in liver fluke-associated cholangiocarcinoma: A target for cholangiocarcinoma treatment.

Cancer science - 1 Jul 2016

Thanee Malinee, Loilome Watcharin, Techasen Anchalee, Sugihara Eiji, Okazaki Shogo, Abe Shinya, Ueda Shiho, Masuko Takashi, Namwat Nisana, Khuntikeo Narong, Titapun Attapol, Pairojkul Chawalit, Saya Hideyuki, Yongvanit Puangrat

Abstract excerpt

Expression of CD44, especially the variant isoforms (CD44v) of this major cancer stem cell marker, contributes to reactive oxygen species (ROS) defense through stabilizing xCT (a cystine-glutamate transporter) and promoting glutathione synthesis. This enhances cancer development and increases chemotherapy resistance. We investigate the role of CD44v in the regulation of the ROS defense system in...

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Identifiers

PMID: 27176078
DOI: 10.1111/cas.12967
PMCID: PMC4946726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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