Article
CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.
Lung cancer (Amsterdam, Netherlands) - 1 Nov 2017
Kawano Yuko, Iwama Eiji, Tsuchihashi Kenji, Shibahara Daisuke, Harada Taishi, Tanaka Kentaro, Nagano Osamu, Saya Hideyuki, Nakanishi Yoichi, Okamoto Isamu
Abstract excerpt
OBJECTIVES: The regulation of redox balance in cancer cells is an important factor in tumor development and chemoresistance, with oncogene activation having been shown to induce the generation of reactive oxygen species (ROS). Activating mutations of the epidermal growth factor receptor gene (EGFR) are oncogenic drivers in non-small cell lung cancer (NSCLC), but it has remained unknown whether ligand-independent...
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