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Article

Role of TFEB-driven autophagy regulation in pancreatic cancer treatment

5 May 2016

Abstract excerpt

Autophagy pathways promote the growth of pancreatic ductal adenocarcinoma (PDAC), but the critical role is yet to be determined. Transcription factor EB (TFEB) centrally controls lysosomal and autophagy biogenesis. This study aimed to explore the role of TFEB for autophagy regulation in PDAC. We found that TFEB expression was significantly elevated in human PDAC samples (n=45), and localized to the cytoplasm and...

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Identifiers

PMID: 27175909
DOI: 10.3892/ijo.2016.3505

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