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Article

TFEB Supports Pancreatic Cancer Growth through the Transcriptional Regulation of Glutaminase

27 Jan 2021

Abstract excerpt

Transcription factor EB (TFEB) is a master regulator of lysosomal function and autophagy. In addition, TFEB has various physiological roles such as nutrient sensing, cellular stress responses, and immune responses. However, the precise roles of TFEB in pancreatic cancer growth remain unclear. Here, we show that pancreatic cancer cells exhibit a significantly elevated TFEB expression compared with normal tissue...

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PMID: 33513833
DOI: 10.3390/cancers13030483

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