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Article

Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis

21 Mar 2019

Abstract excerpt

Impaired macroautophagy/autophagy has been implicated in experimental and human pancreatitis. However, the transcriptional control governing the autophagy-lysosomal process in pancreatitis is largely unknown. We investigated the role and mechanisms of TFEB (transcription factor EB), a master regulator of lysosomal biogenesis, in the pathogenesis of experimental pancreatitis. We analyzed autophagic flux, TFEB...

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Autophagy in Disease and Therapy
Pancreatitis Pathology and Treatment
Phagocytosis and Immune Regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30894069
DOI: 10.1080/15548627.2019.1596486

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