Article

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

2023-05-31

Abstract excerpt

Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ∼10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA repair pathways ( e.g., BRCA2 ). Personalized medicine approaches tailored toward patients’ mutations would improve patients’ outcome. To identify novel vulnerabiliti...

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Literature Corpus work: 7c044067-5a4a-5490-a40e-6cd80b620e39
DOI: 10.1101/2023.05.30.542934

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