Article
Population Pharmacokinetics of Phenytoin Based on NONMEM in Patients with Intracranial Tumor During the First Week of Post-Craniotomy.
Current drug metabolism - 1 Jan 2016
Li Zhong-Dong, Liu Meng, Li Liang, Wan Jing-Hai, Lei Zhaojin, Huang Yong-An
Abstract excerpt
BACKGROUND: It was reported that phenytoin can prevent early post traumatic seizures. The present study aims to establish a population pharmacokinetic (PPK) model of oral phenytoin in patients with intracranial tumor during the early periods, the first week, of post-craniotomy to optimize phenytoin dosage regimen. METHODS: Sixty-two patients with intracranial tumor were genotyped for CYP2C9 and CYP2C19 by real...
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