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Influence of CYP2C9 phenotypes on phenytoin plasma concentration in neurosurgical Brazilian patients.

Pharmacogenetics and genomics - 1 Dec 2024

Kurtz Pedro, Elias Anna Beatriz Ribeiro, Suarez-Kurtz Guilherme

Abstract excerpt

AIMS: To investigate the association of CYP2C9 metabolic phenotypes with phenytoin plasma concentration ([PTH]) in neurosurgical patients from the Brazilian Public Health System. METHODS: Patients (n = 170) were treated with phenytoin (300 mg/day) perioperatively as prophylaxis for postoperative seizures. Two to 10 days after surgery, a blood sample was collected for quantification of [PTH] and genotyping of...

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Adolescent
Anticonvulsants
Brazil
Cytochrome P-450 CYP2C9
Neurosurgical Procedures

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PMID: 39356102
DOI: 10.1097/FPC.0000000000000546

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