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Article

Cisplatin induces tolerogenic dendritic cells in response to TLR agonists via the abundant production of IL-10, thereby promoting Th2- and Tr1-biased T-cell immunity.

Oncotarget - 7 Jun 2016

Kim Woo Sik, Kim Hongmin, Kwon Kee Woong, Im Sin-Hyeog, Lee Bo Ryeong, Ha Sang-Jun, Shin Sung Jae

Abstract excerpt

Although many advantageous roles of cisplatin (cis-diamminedichloroplatinum (II), CDDP) have been reported in cancer therapy, the immunomodulatory roles of cisplatin in the phenotypic and functional alterations of dendritic cells (DCs) are poorly understood. Here, we investigated the effect of cisplatin on the functionality of DCs and the changes in signaling pathways activated upon toll-like receptor (TLR)...

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Identifiers

PMID: 27172902
DOI: 10.18632/oncotarget.9260
PMCID: PMC5085117

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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