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Article

Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures.

Nanoscale - 30 Apr 2021

Michelini Sara, Barbero Francesco, Prinelli Alessandra, Steiner Philip, Weiss Richard, Verwanger Thomas, Andosch Ancuela, Lütz-Meindl Ursula, Puntes Victor F, Drobne Damjana, Duschl Albert, Horejs-Hoeck Jutta

Abstract excerpt

Dendritic cells (DCs) shape immune responses by influencing T-cell activation. Thus, they are considered both an interesting model for studying nano-immune interactions and a promising target for nano-based biomedical applications. However, the accentuated ability of nanoparticles (NPs) to interact with biomolecules may have an impact on DC function that poses an unexpected risk of unbalanced immune reactions....

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PMID: 33928963
DOI: 10.1039/d0nr09153g
PMCID: PMC8087175

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