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Article

Dormant Circulating Tumor Cells in Prostate Cancer: Therapeutic, Clinical and Biological Implications.

Current drug targets - 1 Jan 2016

Alvarez-Cubero Maria J, Vázquez-Alonso Fernando, Puche-Sanz Ignacio, Ortega F Gabriel, Martin-Prieto M, Garcia-Puche José L, Pascual-Geler Manrique, Lorente José A, Cozar-Olmo José M, Serrano Maria J

Abstract excerpt

Circulating Tumor Cells (CTCs) are a valuable prognostic factor in several solid tumors. By understanding the biological characteristics of CTCs we could better understand the biology of metastasis. CTCs usually adopt a dormant state that is believed to be a strategy to survive in extreme conditions. To enter a dormant state, CTCs undergo numerous phenotypic, genetic and functional mutations that significantly...

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PMID: 25751007
DOI: 10.2174/1389450116666150309121346

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