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Article

N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo.

G3 (Bethesda, Md.) - 1 Jun 2016

Itani Omar A, Flibotte Stephane, Dumas Kathleen J, Guo Chunfang, Blumenthal Thomas, Hu Patrick J

Abstract excerpt

Metazoan introns contain a polypyrimidine tract immediately upstream of the AG dinucleotide that defines the 3' splice site. In the nematode Caenorhabditis elegans, 3' splice sites are characterized by a highly conserved UUUUCAG/R octamer motif. While the conservation of pyrimidines in this motif is strongly suggestive of their importance in pre-mRNA splicing, in vivo evidence in support of this is lacking. In an...

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PMID: 27172199
DOI: 10.1534/g3.116.028662
PMCID: PMC4889670

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Source receipt: pubmed, retrieved 7 Sept 2026.

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