Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.

doi:10.1371/journal.pgen.1006000

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Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus.

PLoS genetics - 1 May 2016

Truvé Katarina, Dickinson Peter, Xiong Anqi, York Daniel, Jayashankar Kartika, Pielberg Gerli, Koltookian Michele, Murén Eva, Fuxelius Hans-Henrik, Weishaupt Holger, Swartling Fredrik J, Andersson Göran, Hedhammar Åke, Bongcam-Rudloff Erik, Forsberg-Nilsson Karin, Bannasch Danika, Lindblad-Toh Kerstin

Abstract excerpt

Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may provide insight into disease susceptibility and oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog and Boston Terrier have an elevated risk of...

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PMID: 27171399
DOI: 10.1371/journal.pgen.1006000
PMCID: PMC4865040

Genes

CAMKK2
DENR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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