Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction

Abstract excerpt

Sex-based differences in the immune system influence the clinical course of infectious diseases, including many parasitic infections. Field studies of human infections and controlled experimental rodent models have shown that certain clinical forms of leishmaniasis occur more frequently in males. Leishmania parasites infect and proliferate in innate immune cells, particularly macrophages, and modulate early...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Inflammasome and immune disorders
• Share to interferon and immune responses
• Share to Research on Leishmaniasis Studies