Article
Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.
Antimicrobial agents and chemotherapy - 1 Aug 2016
Nightingale Sam, Chau Tran Thi Hong, Fisher Martin, Nelson Mark, Winston Alan, Else Laura, Carr Daniel F, Taylor Steven, Ustianowski Andrew, Back David, Pirmohamed Munir, Solomon Tom, Farrar Jeremy, Törok M Estée, Khoo Saye
Abstract excerpt
Efavirenz (EFZ) has been associated with neuropsychiatric side effects. Recently, the 8-hydroxy-EFZ (8OH-EFZ) metabolite has been shown to be a potent neurotoxin in vitro, inducing neuronal damage at concentrations of 3.3 ng/ml. EFZ induced similar neuronal damage at concentrations of 31.6 ng/ml. We investigated the effect of genotype and blood-brain barrier integrity on EFZ metabolite concentrations in...
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