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Article

A Hypertension-Associated tRNAAla Mutation Alters tRNA Metabolism and Mitochondrial Function.

Molecular and cellular biology - 15 Jul 2016

Jiang Pingping, Wang Meng, Xue Ling, Xiao Yun, Yu Jialing, Wang Hui, Yao Juan, Liu Hao, Peng Yanyan, Liu Hanqing, Li Haiying, Chen Ye, Guan Min-Xin

Abstract excerpt

In this report, we investigated the pathophysiology of a novel hypertension-associated mitochondrial tRNA(Ala) 5655A → G (m.5655A → G) mutation. The destabilization of a highly conserved base pairing (A1-U72) at the aminoacyl acceptor stem by an m.5655A → G mutation altered the tRNA(Ala) function. An in vitro processing analysis showed that the m.5655A → G mutation reduced the efficiency of tRNA(Ala) precursor 5'...

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Identifiers

PMID: 27161322
DOI: 10.1128/MCB.00199-16
PMCID: PMC4936059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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