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Article

Coronary heart disease is associated with a mutation in mitochondrial tRNA.

Human molecular genetics - 15 Oct 2013

Jia Zidong, Wang Xinjian, Qin Yanwen, Xue Ling, Jiang Pingping, Meng Yanzi, Shi Suxue, Wang Yan, Qin Mo Jun, Guan Min-Xin

Abstract excerpt

Coronary heart disease (CHD) is the leading cause of death worldwide. Mitochondrial genetic determinant for the development of CHD remains poorly explored. We report there the clinical, genetic, molecular and biochemical characterization of a four-generation Chinese family with maternally inherited CHD. Thirteen of 32 adult members in this family exhibited variable severity and age-at-onset of CHD. Mutational...

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Identifiers

PMID: 23736300
DOI: 10.1093/hmg/ddt256
PMCID: PMC3781636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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