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Article

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.

Molecular cell - 5 May 2016

Akabane Shiori, Uno Midori, Tani Naoki, Shimazaki Shunta, Ebara Natsumi, Kato Hiroki, Kosako Hidetaka, Oka Toshihiko

Abstract excerpt

A mitochondrial kinase, PTEN-induced putative kinase 1 (PINK1), selectively recruits the ubiquitin ligase Parkin to damaged mitochondria, which modifies mitochondria by polyubiquitination, leading to mitochondrial autophagy. Here, we report that treatment with an adenylate cyclase agonist or expression of protein kinase A (PKA) impairs Parkin recruitment to damaged mitochondria and decreases PINK1 protein levels....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27153535
DOI: 10.1016/j.molcel.2016.03.037

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.PMID 27153535Read ↗

PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista JunctionsSemantic proximity Read ↗

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagySemantic proximity Read ↗

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment.Semantic proximity Read ↗

Ubiquitin is phosphorylated by PINK1 to activate parkin.Semantic proximity Read ↗

MOLECULAR BASIS FOR PINK1 MATURATIONSemantic proximity Read ↗

KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagySemantic proximity Read ↗

Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility.Semantic proximity Read ↗

The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in DrosophilaSemantic proximity Read ↗

Identification and structural characterization of small-molecule inhibitors of PINK1Semantic proximity Read ↗

Phosphorylation of MCAD selectively rescues PINK1 deficiencies in behavior and metabolism.Semantic proximity Read ↗

D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane.Semantic proximity Read ↗

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.Semantic proximity Read ↗

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