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A Case of Sinonasal Melanoma With Unusual Primary Exon 17 KIT D820G Mutation.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000

Pilozzi Emanuela, Bartolazzi Armando, Fochetti Flavio, Duranti Enrico, Scarpino Stefania, Valeriani Maurizio, Moriconi Piero, Ruco Luigi

Abstract excerpt

Sinonasal melanomas are rare neoplasms with poor prognosis that may harbor KIT and NRAS genes mutations. Molecular alterations represent possible targets of tailored therapeutic approaches. We describe the case of a 74-year-old patient with primary melanoma of the nasal cavity. Mutational analysis of KIT demonstrated a point missense mutation D820G in exon 17. This represents, to our knowledge, the first case of...

Topics

Aged
Exons
Humans
Male
Melanoma
Mutation
Nose Neoplasms
Paranasal Sinuses
Proto-Oncogene Proteins c-kit

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27153441
DOI: 10.1097/PAI.0000000000000346

Genes

KIT
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A Case of Sinonasal Melanoma With Unusual Primary Exon 17 KIT D820G Mutation.PMID 27153441Read ↗

Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations.Semantic proximity Read ↗

Sinonasal mucosal melanoma: Molecular profile and therapeutic implications from a series of 32 cases.Semantic proximity Read ↗

Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature.Semantic proximity Read ↗

KIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases.Semantic proximity Read ↗

Mutation status among patients with sinonasal mucosal melanoma and its impact on survivalSemantic proximity Read ↗

Novel somatic KIT exon 8 mutation with dramatic response to imatinib in a patient with mucosal melanoma: a case report.Semantic proximity Read ↗

BRAF, NRAS, KIT, TERT, GNAQ/GNA11 mutation profile analysis of head and neck mucosal melanomas: a study of 42 cases.Semantic proximity Read ↗

KIT Mutation Incidence and Pattern of Melanoma in Central Europe.Semantic proximity Read ↗

SF3B1, NRAS, KIT, and BRAF Mutation; CD117 and cMYC Expression; and Tumoral Pigmentation in Sinonasal MelanomasSemantic proximity Read ↗

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Novel somatic Missense Mutations in Exon 11 of the KIT Gene are Detected in Melanoma.Semantic proximity Read ↗

KIT Somatic Mutations and Immunohistochemical Expression in Canine Oral MelanomaSemantic proximity Read ↗

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