Article
Oncogene abnormalities in a series of primary melanomas of the sinonasal tract: NRAS mutations and cyclin D1 amplification are more frequent than KIT or BRAF mutations.
Human pathology - 1 Sept 2013
Chraybi Meriem, Abd Alsamad Issam, Copie-Bergman Christiane, Baia Maryse, André Jocelyne, Dumaz Nicolas, Ortonne Nicolas
Abstract excerpt
Primary malignant melanoma of sinonasal tract is a rare but severe form of melanoma. We retrospectively analyzed 17 cases and focused on the histologic presentation and the expression of c-Kit, epidermal growth factor receptor (EGFR), cyclin D1/Bcl-1, PS100, and HMB45 and searched for BRAF, NRAS, and KIT mutations that are known to be associated with melanoma subtypes, together with amplifications of KIT, cyclin...
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