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Article

Detection of RAS mutations in archival testicular germ cell tumors by polymerase chain reaction and oligonucleotide hybridization.

Genes, chromosomes & cancer - 1 Sept 1992

Moul J W, Theune S M, Chang E H

Abstract excerpt

Preliminary studies of RAS mutational activation in human testicular germ cell neoplasms have yielded conflicting results. Whereas two studies of clinical material revealed a significant incidence of N- and KRAS mutations, two studies of a variety of germ cell lines failed to document RAS mutations. To clarify the incidence of RAS mutations in these tumors, we studied archival paraffin-embedded, formalin-fixed...

Topics

Blotting, Southern
Genes, ras
Humans
Leydig Cell Tumor
Male
Mutation
Neoplasms, Germ Cell and Embryonal
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Testicular Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1381946
DOI: 10.1002/gcc.2870050204

Genes

KRAS
HRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1381946-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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