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Article

Molecular Understanding of the Acquisition of Resistance to Anti-cancer Drugs Associated with the Exacerbation of Cancer.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Jan 2016

Kuzumaki Naoko, Narita Michiko, Ikegami Daigo, Narita Minoru

Abstract excerpt

Gefitinib and erlotinib target the ATP cleft in the tyrosine kinase EGFR, which is overexpressed in 40-80 percent of non-small-cell lung cancer (NSCLC) and many other epithelial cancers. However, the application of gefitinib is ultimately limited by the emergence of mutations and other molecular mechanisms conferring drug resistance. Furthermore, it has been considered that acquired resistance to gefitinib is...

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Source

Identifiers

PMID: 27150922
DOI: 10.1248/yakushi.15-00262-3

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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