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Article

Insights into the negative regulation of EGFR upon the binding of an allosteric inhibitor.

Chemical biology & drug design - 1 Apr 2022

Li Miaomiao, Xu Yan, Guo Jingjing

Abstract excerpt

Epidermal growth factor receptor (EGFR) is an intensively focused drug target for non-small cell lung cancer (NSCLC). JBJ-04-125-02 is an effective ATP-noncompetitive and T790M/L858R-selective inhibitor of EGFR, but the implied negative regulation mechanism is not fully clarified. Here, computational approaches were employed to address this. We find that JBJ-04-125-02 induces contrary effects on the binding of...

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Identifiers

PMID: 35152550
DOI: 10.1111/cbdd.14033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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