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Article

Conversion from the "oncogene addiction" to "drug addiction" by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2012

Suda Kenichi, Tomizawa Kenji, Osada Hirotaka, Maehara Yoshihiko, Yatabe Yasushi, Sekido Yoshitaka, Mitsudomi Tetsuya

Abstract excerpt

Emergence of acquired resistance is virtually inevitable in patients with a mutation in the epidermal growth factor receptor gene (EGFR) treated with EGFR tyrosine kinase inhibitors (TKIs). Several novel TKIs that may prevent or overcome the resistance mechanisms are now under clinical development. However, it is unknown how tumor cells will respond to intensive treatment using these novel TKIs. We previously...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22133747
DOI: 10.1016/j.lungcan.2011.11.007

Genes

EGFR
MET
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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