Article
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
Cancer research - 15 May 2013
Shien Kazuhiko, Toyooka Shinichi, Yamamoto Hiromasa, Soh Junichi, Jida Masaru, Thu Kelsie L, Hashida Shinsuke, Maki Yuho, Ichihara Eiki, Asano Hiroaki, Tsukuda Kazunori, Takigawa Nagio, Kiura Katsuyuki, Gazdar Adi F, Lam Wan L, Miyoshi Shinichiro
Abstract excerpt
Acquired resistance to EGF receptor (EGFR) tyrosine kinase inhibitor (TKI) is a critical problem in the treatment of lung cancer. Although several mechanisms have been shown to be responsible for acquired resistance, all mechanisms have not been uncovered. In this study, we investigated the molecular and cellular profiles of the acquired resistant cells to EGFR-TKI in EGFR-mutant lung cancers. Four EGFR-mutant...
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