Article
Parkinson's disease-associated protein Parkin: an unusual player in cancer.
Cancer communications (London, England) - 26 Jun 2018
Liu Juan, Zhang Cen, Hu Wenwei, Feng Zhaohui
Abstract excerpt
The mutation of the Parkin gene is a cause of familial Parkinson's disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review the role...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.