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Article

Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress.

Neuroscience letters - 25 Jul 2008

Yu Furong, Zhou Jianhua

Abstract excerpt

Parkin plays an important role in the pathogenesis of Parkinson's disease. We previously described that Nrdp1, a RING-finger ubiquitin E3 ligase, interacted with Parkin by the yeast two-hybrid assay and by co-immunoprecipitation. Here we further demonstrated that overexpression of Nrdp1 significantly reduced the endogenous Parkin level in an Nrdp1 dosage-dependent and proteasome-dependent manner. More...

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Source

Identifiers

PMID: 18541373
DOI: 10.1016/j.neulet.2008.05.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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