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Article

Parkin exerts the tumor‐suppressive effect through targeting mitochondria

14 Mar 2023

Abstract excerpt

The role of PARKIN in Parkinson's disease is well established but its role in cancer has recently emerged. PARKIN serves as a tumor suppressor in many cancers and loses the tumor-suppressive function due to loss of heterozygosity and DNA copy number. But how PARKIN protects against cancer is poorly understood. Through the analysis of PARKIN substrates and their association with mitochondria, this viewpoint...

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Share to Autophagy in Disease and Therapy
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PMID: 36916678
DOI: 10.1002/med.21938

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