Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

22 Feb 2022

Abstract excerpt

Limited understanding of bladder cancer aetiopathology hampers progress in reducing incidence. Mutational signatures show the anti-viral apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) enzymes are responsible for the preponderance of mutations in bladder tumour genomes, but no causative viral agent has been identified. BK polyomavirus (BKPyV) is a common childhood infection that remains latent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Polyomavirus and related diseases
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35194151
DOI: 10.1038/s41388-022-02235-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancerPMID 35194151Read ↗

BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damageSemantic proximity Read ↗

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation.Semantic proximity Read ↗

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by PolyomavirusesSemantic proximity Read ↗

Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection.Semantic proximity Read ↗

Donor‐derived, metastatic urothelial cancer after kidney transplantation associated with a potentially oncogenic BK polyomavirusSemantic proximity Read ↗

Evidence for Virus-Mediated Oncogenesis in Bladder Cancers Arising in Solid Organ Transplant RecipientsSemantic proximity Read ↗

Viral integration in BK polyomavirus-associated urothelial carcinoma in renal transplant recipients: multistage carcinogenesis revealed by next-generation virome capture sequencingSemantic proximity Read ↗

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune responseSemantic proximity Read ↗

BK polyomavirus: latency, reactivation, diseases and tumorigenesisSemantic proximity Read ↗

Potential of APOBEC3B as a therapeutic target and its role in bladder cancer onset and progressionSemantic proximity Read ↗

Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipientsSemantic proximity Read ↗

DNA Rearrangements Impairing BK Virus Productive Infection in Urinary Tract TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.