A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis.

doi:10.18632/oncotarget.9056

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis.

Oncotarget - 31 May 2016

Wang Ying, Wu Xue-Song, He Jing, Ma Tianjiao, Lei Wei, Shen Zhen-Ya

Abstract excerpt

Polymorphisms in TP53 are involved in the progression of different types of cancer. A rare novel TP53 variant (rs78378222 A > C allele) was found via whole-genome sequencing in 2011. This variant was shown to significantly increase the risk of glioma, colorectal adenoma and prostate cancer. Functional analysis further revealed that this variant hindered TP53 expression and its downstream effect on apoptosis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Neoplasms

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Share to Risk Assessment

Share to Risk Factors

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 27147571
DOI: 10.18632/oncotarget.9056
PMCID: PMC5078057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel TP53 variant (rs78378222 A > C) in the polyadenylation signal is associated with increased cancer susceptibility: evidence from a meta-analysis.PMID 27147571Read ↗

A functional germline variant in the P53 polyadenylation signal and risk of esophageal squamous cell carcinoma.Semantic proximity Read ↗

A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.Semantic proximity Read ↗

Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data.Semantic proximity Read ↗

Rare variants in TP53 and susceptibility to neuroblastoma.Semantic proximity Read ↗

Mutational Landscape of TP53 Across Cancer TypesSemantic proximity Read ↗

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222.Semantic proximity Read ↗

Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors.Semantic proximity Read ↗

Association between the WRAP53 gene rs2287499 C>G polymorphism and cancer risk: A meta-analysis.Semantic proximity Read ↗

Association between rs735482 polymorphism and risk of cancer: A meta-analysis of 10 case-control studies.Semantic proximity Read ↗

Rare TP53 genetic variant associated with glioma risk and outcome.Semantic proximity Read ↗

Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant.Semantic proximity Read ↗

Evaluation of the p53 Arg72Pro polymorphism and its association with cancer risk: a HuGE review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.