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Article

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.

Scientific reports - 5 May 2016

Eastman Richard T, Khine Pwint, Huang Ruili, Thomas Craig J, Su Xin-Zhuan

Abstract excerpt

Treatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic regions. ACTs combine ART or its derivative with a long-acting partner drug to maximize efficacy during the typical three-day regimen. Both laboratory and clinical studies have previously demonstrated that the common drug resistance determinants P. falciparum...

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Identifiers

PMID: 27147113
DOI: 10.1038/srep25379
PMCID: PMC4857081

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