Rare variant association analysis methods for complex traits.

Abstract excerpt

There has been increasing interest in rare variants and their association with disease, and several rare variant-disease associations have already been detected. The usual association tests for common variants are underpowered for detecting variants of lower frequency, so alternative approaches are required. In addition to reviewing the association analysis methods for rare variants, we discuss the limitations of...

Topics

• Animals
• Disease
• Genetic Association Studies
• Genome-Wide Association Study
• Humans
• Mutation