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Article

Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Aug 2016

Schiele Miriam A, Ziegler Christiane, Holitschke Karoline, Schartner Christoph, Schmidt Brigitte, Weber Heike, Reif Andreas, Romanos Marcel, Pauli Paul, Zwanzger Peter, Deckert Jürgen, Domschke Katharina

Abstract excerpt

Environmental vulnerability factors such as adverse childhood experiences in interaction with genetic risk variants, e.g., the serotonin transporter gene linked polymorphic region (5-HTTLPR), are assumed to play a role in the development of anxiety and affective disorders. However, positive influences such as general self-efficacy (GSE) may exert a compensatory effect on genetic disposition, environmental...

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Identifiers

PMID: 27145764
DOI: 10.1007/s00702-016-1564-z

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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