Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology.

Neurobiology of aging - 1 Jun 2016

Scheff Stephen W, Ansari Mubeen A, Mufson Elliott J

Abstract excerpt

Neuritic amyloid plaques and neurofibrillary tangles are hallmarks of Alzheimer's disease (AD) and are major components used for the clinical diagnosis of this disorder. However, many individuals with no cognitive impairment (NCI) also present at autopsy with high levels of these AD pathologic hallmarks. In this study, we evaluated 15 autopsy cases from NCI individuals with high levels of AD-like pathology (high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cognition

Share to Hippocampus

Share to Lipid Peroxidation

Share to Oxidative Stress

Share to Peptide Fragments

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 27143416
DOI: 10.1016/j.neurobiolaging.2016.02.030
PMCID: PMC4857887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology.PMID 27143416Read ↗

Synaptic dysfunction and oxidative stress in Alzheimer's disease: Emerging mechanismsSemantic proximity Read ↗

Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia.Semantic proximity Read ↗

Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease.Semantic proximity Read ↗

The morphologic and neurochemical basis of dementia: aging, hierarchical patterns of lesion distribution and vulnerable neuronal phenotype.Semantic proximity Read ↗

Relationship between Cognitive Dysfunction and Age-Related Variability in Oxidative Markers in Isolated Mitochondria of Alzheimer’s Disease Transgenic Mouse BrainsSemantic proximity Read ↗

Changes in the ageing brain in health and diseaseSemantic proximity Read ↗

Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteinsSemantic proximity Read ↗

Alzheimer neuropathologic alterations in aged cognitively normal subjects.Semantic proximity Read ↗

Alzheimer's disease and post-operative cognitive dysfunction.Semantic proximity Read ↗

Neurodegenerative changes in human aging brain. An autopsy study.Semantic proximity Read ↗

Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s diseaseSemantic proximity Read ↗

A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.