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Synaptic dysfunction and oxidative stress in Alzheimer's disease: Emerging mechanisms

1 Jul 2006

Abstract excerpt

In this paper, we review experimental advances in molecular neurobiology of Alzheimer's disease (AD), with special emphasis on analysis of neural function of proteins involved in AD pathogenesis, their relation with several signaling pathways and with oxidative stress in neurons. Molecular genetic studies have found that mutations in APP, PS1 and PS2 genes and polymorphisms in APOE gene are implicated in AD...

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PMID: 16989739
DOI: 10.1111/j.1582-4934.2006.tb00439.x

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