Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenomics in pediatric leukemia.

Current opinion in pediatrics - 1 Dec 2010

Paugh Steven W, Stocco Gabriele, Evans William E

Abstract excerpt

PURPOSE OF REVIEW: The therapeutic index of many medications, especially in children, is very narrow with substantial risk for toxicity at doses required for therapeutic effects. This is particularly relevant to cancer chemotherapy, when the risk of toxicity must be balanced against potential suboptimal (low) systemic exposure that can be less effective in patients with higher rates of drug clearance. The purpose...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Child
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Pharmacogenetics

Share to Phenotype

Share to Precision Medicine

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 20861736
DOI: 10.1097/MOP.0b013e32833fde85
PMCID: PMC3612020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenomics in pediatric leukemia.PMID 20861736Read ↗

Pharmacogenomics in cancer treatment defining genetic bases for inter-individual differences in responses to chemotherapy.Semantic proximity Read ↗

Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine.Semantic proximity Read ↗

Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Pharmacogenetic considerations for acute lymphoblastic leukemia therapies.Semantic proximity Read ↗

Pharmacogenomic Profiling of Pediatric Acute Myeloid Leukemia to Identify Therapeutic Vulnerabilities and Inform Functional Precision MedicineSemantic proximity Read ↗

Pharmacogenetics in acute lymphoblastic leukemia.Semantic proximity Read ↗

Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review)Semantic proximity Read ↗

Pediatric pharmacogenetic and pharmacogenomic studies: the current state and future perspectives.Semantic proximity Read ↗

Pharmacogenetics influence treatment efficacy in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients.Semantic proximity Read ↗

Using Germline Genomics to Individualize Pediatric Cancer TreatmentsSemantic proximity Read ↗

Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.